A close friend of mine is in one of the double-blind trials here in the US. He e... | Hacker News

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		sokoloff on Dec 27, 2020 \| parent \| context \| favorite \| on: How a British Covid-19 vaccine went from pole posi... A close friend of mine is in one of the double-blind trials here in the US. He experienced symptoms 36-48 hours after the injection that have him convinced that he got an active vaccine dose. He has (by my judgment not his words) altered his routines as a result. That seems a mechanism by which the blinding can be undone (though in this case, it would seem to work against computed vaccine efficacy rather than for it).

disgruntledphd2 on Dec 27, 2020 [–]

Yeah, ideally you'd use an active placebo (same side effects as the active drug) but that's hard to do well and presumably wasn't a priority.

tim333 on Dec 27, 2020 | [–]

For at least some of the Oxford trials they used a "widely available meningitis vaccine."

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