Same for trains. I wouldn’t take the LIRR to JFK or Caltrain to SFO if I had to bike with my luggage or whatever. And I’m not adding an hour to my trip for the bus.
You'll be able to pay more to take a single dedicated vehicle the whole way, or less that includes a self-driving bus or two for most of the middle segment of your journey.
But the bus "routes" will be totally dynamic based on demand, and will only stop occasionally, and you won't have to wait long.
It's going to be a complete revolution in public transit.