Why not Raid 60 with Btrfs? It'll tolerate two disk loss with pro-active parity protection via btrfs and be faster and provide you with more disk space.
Do you feel comfortable with reliability of btrfs?
When I do a Google search, I want to see confirmed cases of fs lockups / data loss from fs bugs to be multiple years in the past. btrfs isn't there yet.
I like btrfs's ability to e.g. switch raid levels without offlining the array. I think it's promising. But I wouldn't trust my data to it tomorrow.
For a home NAS intended to stream video, my experience is 'no, don't'. I ran btrfs on my home NAS (on mdadm RAID1), and playing video from it was awful - pausing every few minutes. I thought it was just my misconfiguration of samba, but a rebuild using xfs fixed it, and a friend having the same problems on a btrfs (no raid) home media server now make me gun-shy. I don't need the benefits btrfs has on my box, so I'll stick with xfs.
I am very much not a filesystem expert, but my experience is that for me, btrfs is no benefits and significant problems.