That's a bit misleading. Reverse engineering has, on the face, little to do with assembler of any sort; it's about understanding your target and choosing the best angle of attack to learn more about it. That often depends on how the target was produced in the first place. If it's written in C or C++, sure, go to the assembler. If it's some Adobe Air program that is really just a launcher for a SWF, well, you're not going to have much luck. Similarly, the application logic in a program like EVE Online is almost entirely written in Python; you wouldn't exactly know it from the outside, because they've wrapped all the native things they need. But then you won't learn much either just looking at the assembly of what are various layers and layers of wrappers.